Producción de agregados reciclados de los residuos de la Construcción y Demolición para la producción de concretos Hidráulicos en la Ciudad de Juliaca

En el mundo de la construcción la producción de concreto es fundamental, para su elaboración se necesita la mezcla de agregados agua y cemento, el agregado es un elemento que es extraída de canteras naturales. La construcción si bien es cierto es una manera de desarrollo, también trae consigo problemas ambientales como es la depredación de canteras naturales que modifican el medio, y por otro lado los desperdicios acumulados por demolición que acarrean desmontes. El presente trabajo pretende demostrar que se puede reemplazar los agregados naturales con agregado reciclados producto de los residuos de la construcción y demolición para producir concretos hidráulicos nuevos, para tal fin dichos agregados deben tener un proceso de selección y mecanismo de tratamiento con la finalidad de mejorar sus propiedades físicas y mecánicas. Para esta investigación los agregados reciclados se obtuvieron de la demolición de una plataforma ubicada en la facultad de Ingenierías y Ciencias Puras de la UANCV con la finalidad de construir una vía nueva, estos desechos tuvieron un proceso de selección y un mecanismo de tratamiento que incluye una limpieza adecuada, trituración, clasificación manual mediante la malla N° 4 para separar el agregado grueso del fino con el objeto de usar solo el agregado grueso reciclado; el agregado fino utilizado es de una cantera natural. El agregado grueso reciclado tratado fue sometido a diferentes ensayos en laboratorio para obtener sus propiedades físicas y mecánicas y efectuar un diseño de mezcla para una resistencia a la compresión de f´c= 210 kg/cm2, se ha elegido esta resistencia porque la plataforma demolida tuvo este diseño según el expediente técnico y el ensayo de prueba de resistencia a la compresión diamantina que se realizó ínsito. Se produjo concretos nuevos con la ayuda de una Mezcladora Tipo Trompo 9 P3 con motor gasolinera de 9 Hp a 3600 RPM y se propuso 3 combinaciones en los agregados gruesos: 100% agregado grueso reciclado, 80% agregado grueso reciclado y 20% agregado grueso natural, 50% agregado grueso reciclado y 50% agregado grueso natura, estos agregados mezclados con cemento, agua y agregado fino natural según dosificación del diseño de mezclas. El concreto se moldeó en briquetas y se realizó el curado respectivo para prevenir la perdida de humedad mientras se mantiene un régimen satisfactorio de temperatura, luego se encontró su resistencia a la compresión con la prensa hidráulica a los 6, 7, 14, 21 y 28 días, los resultados demostraron que con la primera combinación alcanzó a los 28 días 81.73%, con la segunda combinación alcanzo a 84.51% y con la tercera combinación a 107.22%. Quiere decir que un concreto con agregado reciclado puede ser usado en elementos estructurales.Tesi

New vegetation history reconstructions suggest a biostratigraphic assignment of the lowermost Rodderberg interglacial (Germany) to MIS 11

Along with the ongoing climate crisis, research efforts increasingly focus on Pleistocene environmental archives. Interglacial periods are of special interest, as they offer crucial information about natural interactions (i.e. not influenced by human activities) between climate and ecosystems within a climatic setting comparable to the Holocene and/or climate change projections. The sedimentary infill of the Rodderberg crater, 10 km south of the city of Bonn (Germany), records several glacial-interglacial cycles in superposition, which makes it a rare and promising environmental archive. One of the most challenging targets is to establish a robust chronological framework for the Rodderberg sediment sequence. In the present study we reconstruct the vegetation history of the basal and most prominent interglacial sequence, the lowermost Rodderberg interglacial (LRI), and apply the principles of pollen biostratigraphy to estimate the depositional age. At the base of the sequence steppe tundra conditions prevailed during the cryocratic phase before the onset of the interglacial. Rising temperatures caused afforestation of the landscape with boreal forests during the protocratic phase, which subsequently were replaced by temperate forests in the mesocratic phase. The sequence continues under unstable vegetation conditions characterized by temperate forests dominated by Carpinus and Abies during the oligocratic phase. During the terminal part of the LRI, the telocratic phase, boreal to nemoboreal forests covered the landscape. Due to climatic deterioration these forests collapsed and a steppe tundra evolved again (cryocratic phase). This climate-driven glacial-interglacial cycle is followed by an interstadial with rather closed nemoboreal forest vegetation. Based on the occurrences of characteristic taxa as well as the vegetation assemblages and succession, we refrain from correlating the LRI with any of the warm stages between c. 240 and 180 ka BP, i.e. roughly corresponding to MIS 7. A correlation with the Holsteinian, which was previously physically dated to c. 340e325 ka BP, cannot unambiguously be excluded, however, the absence of Pterocarya during the LRI argues against it. Instead, the LRI has striking similarities with the Kärlich interglacial, which has been previously physically dated to c. 400 ka BP, making it chronologically equivalent to MIS 11

Palynological investigations reveal Eemian interglacial vegetation dynamics at Spiezberg, Bernese Alps, Switzerland

Interglacial pollen records are valuable archives of past vegetation dynamics and provide important information about vegetation responses to different-than-today climates. Interglacial pollen archives pre-dating the Last Glacial Maximum (LGM) are scarce on the Swiss Plateau in contrast to the many available Late Glacial and Holocene records. This is mainly due to the rapidly changing palaeo- environmental conditions throughout the Quaternary and the low preservation potential of material suitable for palynological investigations. The Spiezberg site offers a palynological record situated most proximal to the Alps in Switzerland. Previous investigations tentatively assigned this record to the Eemian interglacial (MIS 5e). We have conducted additional pollen analytical investigations to increase the quantity of pollen information. Besides biostratigraphic interpretations, we use numerical methods such as distance analysis (distantia) and ordination techniques (PCA) to evaluate the similarities and differences between the Spiezberg record and its geographically and chronostratigraphically closest physically dated (U/Th, luminescence) analogues from the Eemian (MIS 5e) and Meikirch 3 (MIS 7a) interglacials. Our palynological investigations reveal the predominance of closed temperate forests with abundant fir (Abies) and spruce (Picea) as well as evergreen broad-leaved taxa (e.g. Hedera). The attri- bution to the Eemian interglacial relies on the observation of very rare beech (Fagus) occurrences, a phase with prominent yew (Taxus) and the unimportance of hornbeam (Carpinus), all of which are typical Eemian features on the Swiss Plateau. An Eemian age is supported by the numerical comparison with the Beerenmo€sli (MIS 5e) and Meikirch 3 (MIS 7a) reference records. Furthermore, the Picea, Taxus and Fagus dynamics observed on the Swiss Plateau during the Eemian are in excellent agreement with vegetational patterns observed elsewhere in Central Europe. Surprisingly, Carpinus was almost absent on the Swiss Plateau during the Eemian, whereas it was a major component of the forest at other European sites with a similar elevation as Spiezberg. We explain this by environmental conditions and the strong competition with Abies alba. In particular, considering the European Eemian vegetation history and the results of our reconstructions from the Swiss Plateau, we find that Abies alba was a highly competitive tree under natural warmer-than-today conditions. This finding provides further evidence that Abies alba may benefit from future climate warming

Macaque models of human infectious disease.

Macaques have served as models for more than 70 human infectious diseases of diverse etiologies, including a multitude of agents-bacteria, viruses, fungi, parasites, prions. The remarkable diversity of human infectious diseases that have been modeled in the macaque includes global, childhood, and tropical diseases as well as newly emergent, sexually transmitted, oncogenic, degenerative neurologic, potential bioterrorism, and miscellaneous other diseases. Historically, macaques played a major role in establishing the etiology of yellow fever, polio, and prion diseases. With rare exceptions (Chagas disease, bartonellosis), all of the infectious diseases in this review are of Old World origin. Perhaps most surprising is the large number of tropical (16), newly emergent (7), and bioterrorism diseases (9) that have been modeled in macaques. Many of these human diseases (e.g., AIDS, hepatitis E, bartonellosis) are a consequence of zoonotic infection. However, infectious agents of certain diseases, including measles and tuberculosis, can sometimes go both ways, and thus several human pathogens are threats to nonhuman primates including macaques. Through experimental studies in macaques, researchers have gained insight into pathogenic mechanisms and novel treatment and vaccine approaches for many human infectious diseases, most notably acquired immunodeficiency syndrome (AIDS), which is caused by infection with human immunodeficiency virus (HIV). Other infectious agents for which macaques have been a uniquely valuable resource for biomedical research, and particularly vaccinology, include influenza virus, paramyxoviruses, flaviviruses, arenaviruses, hepatitis E virus, papillomavirus, smallpox virus, Mycobacteria, Bacillus anthracis, Helicobacter pylori, Yersinia pestis, and Plasmodium species. This review summarizes the extensive past and present research on macaque models of human infectious disease

Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients

Background: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are associated with poor prognosis in breast cancer patients. To confirm the prognostic value of uPA and PAI-1 in primary breast cancer, we reanalyzed individual patient data provided by members of the European Organization for Research and Treatment of Cancer-Receptor and Biomarker Group (EORTC-RBG). Methods: The study included 18 datasets involving 8377 breast cancer patients. During follow-up (median 79 months), 35% of the patients relapsed and 27% died. Levels of uPA and PAI-1 in tumor tissue extracts were determined by different immunoassays; values were ranked within each dataset and divided by the number of patients in that dataset to produce fractional ranks that could be compared directly across datasets. Associations of ranks of uPA and PAI-1 levels with relapse-free survival (RFS) and overall survival (OS) were analyzed by Cox multivariable regression analysis stratified by dataset, including the following traditional prognostic variables: age, menopausal status, lymph node status, tumor size, histologic grade, and steroid hormone-receptor status. All P values were two-sided. Results: Apart from lymph node status, high levels of uPA and PAI-1 were the strongest predictors of both poor RFS and poor OS in the analyses of all patients. Moreover, in both lymph node-positive and lymph node-negative patients, higher uPA and PAI-1 values were independently associated with poor RFS and poor OS. For (untreated) lymph node-negative patients in particular, uPA and PAI-1 included together showed strong prognostic ability (all P<.001). Conclusions: This pooled analysis of the EORTC-RBG datasets confirmed the strong and independent prognostic value of uPA and PAI-1 in primary breast cancer. For patients with lymph node-negative breast cancer, uPA and PAI-1 measurements in primary tumors may be especially useful for designing individualized treatment strategie

Late 1920s film theory and criticism as a test-case for Benjamin’s generalizations on the experiential effects of editing

This article investigates Walter Benjamin’s influential generalization that the effects of cinema are akin to the hyper-stimulating experience of modernity. More specifically, I focus on his oft-cited 1935/36 claim that all editing elicits shock-like disruption. First, I propose a more detailed articulation of the experience of modernity understood as hyper-stimulation and call for distinguishing between at least two of its subsets: the experience of speed and dynamism, on the one hand, and the experience of shock/disruption, on the other. Then I turn to classical film theory of the late 1920s to demonstrate the existence of contemporary views on editing alternative to Benjamin’s. For instance, whereas classical Soviet and Weimar theorists relate the experience of speed and dynamism to both Soviet and classical Hollywood style editing, they reserve the experience of shock/disruption for Soviet montage. In order to resolve the conceptual disagreement between these theorists, on the one hand, and Benjamin, on the other, I turn to late 1920s Weimar film criticism. I demonstrate that, contrary to Benjamin’s generalizations about the disruptive and shock-like nature of all editing, and in line with other theorists’ accounts, different editing practices were regularly distinguished by comparison to at least two distinct hyper-stimulation subsets: speed and dynamism, and shock-like disruption. In other words, contemporaries regularly distinguished between Soviet montage and classical Hollywood editing patterns on the basis of experiential effects alone. On the basis of contemporary reviews of city symphonies, I conclude with a proposal for distinguishing a third subset – confusion. This is an original manuscript / preprint of an article published by Taylor & Francis in Early Popular Visual Culture on 02 Aug 2016 available online: https://doi.org/10.1080/17460654.2016.1199322

Tree rings reveal globally coherent signature of cosmogenic radiocarbon events in 774 and 993 CE

This study was funded by the WSL-internal COSMIC project (5233.00148.001.01), the ETHZ (Laboratory of Ion Beam Physics), the Swiss National Science Foundation (SNF Grant 200021L_157187/1), and as the Czech Republic Grant Agency project no. 17-22102s.Though tree-ring chronologies are annually resolved, their dating has never been independently validated at the global scale. Moreover, it is unknown if atmospheric radiocarbon enrichment events of cosmogenic origin leave spatiotemporally consistent fingerprints. Here we measure the 14C content in 484 individual tree rings formed in the periods 770–780 and 990–1000 CE. Distinct 14C excursions starting in the boreal summer of 774 and the boreal spring of 993 ensure the precise dating of 44 tree-ring records from five continents. We also identify a meridional decline of 11-year mean atmospheric radiocarbon concentrations across both hemispheres. Corroborated by historical eye-witness accounts of red auroras, our results suggest a global exposure to strong solar proton radiation. To improve understanding of the return frequency and intensity of past cosmic events, which is particularly important for assessing the potential threat of space weather on our society, further annually resolved 14C measurements are needed.Publisher PDFPeer reviewe

Lessons Learned from the Numerical Investigations on the VFE-2 Configuration

The Second International Vortex Flow Experiment provided a variety of experimental data for a 65° delta wing with sharp and blunt/rounded leading edges. Flow measurements including forces and moments, surface pressures, Pressure Sensitive Paint measurements, and off-surface flow variables from Particle Image Velocimetry were made available for comparisons with computational simulations. A number of test cases were chosen for simulation by seven numerical groups, and a summary of their results is presented here. The ability of computational fluid dynamics to predict such flow features as the dual primary vortex system found on the blunt leading edge configuration and a shock/vortex interaction for the sharp leading edge are assessed. While computational simulation has made great strides in recent years, there are still areas where further improvement can be made, including in turbulence modeling, transition modeling, and the ability to accurately compute unsteady flows